Assoc. Scientific Director, Antibody Engineering

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visitneurocrine.com, and follow the company on LinkedIn, X (Formerly Twitter) and Facebook. (*in collaboration with AbbVie)

About the Role:

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• Leads a protein engineering team in discovering, assaying, engineering, reformatting antibodies and biologics

• Responsible for resource allocation to achieve team and project goals within a defined budget

• Actively manage and develop a high performing team of protein engineers

• Develop and deliver scientific presentations, prepare clear and concise technical reports, participate or lead project teams

• Contributes to development of policies, SOPs, and department strategies

• Monitor and incorporate the latest developments in the biologic therapeutic space for opportunities that will keep Neurocrine's franchises current and competitive

• Presents data and strategies at varying levels across the company

• Other duties as assigned

• BS/BA in Analytical Chemistry or related discipline and 10+ years of experience in pharmaceutical research or development OR

• MS/MA in Analytical Chemistry or related discipline and 8+ years of experience

• PhD in Analytical Chemistry or related discipline and 5+ years of relevant experience; may include postdoc experience

• Previous managerial / functional management experience also required

• Industry leading knowledge of state-of-the-art protein engineering concepts and techniques

• Practical experience with affinity determination methods, and execution of antibody optimization campaigns using directed evolution screening platforms

• Protein expression, purification and analysis

• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)

• MAbs/bi specifics - Proven success in the ability to apply protein engineering principles to mAb & BiSp design

• Knowledge of immunogenicity & antibody effector assays

• Advanced knowledge of protein structure function relationships

• Ability to utilize bioinformatics software for protein and gene analyses

• Excellent interpersonal skills with strong oral and written communication abilities

• Excellent laboratory skills and proven productivity

• Method development, validation, and transfer experience in process development a plus

• Expert knowledge of cross-functional understanding related to drug development

• Proven strong track record in advanced experimental technologies and their utilization in the drug discovery process

• Experience with delivery of biologics across the blood brain barrier a plus

• Excellent critical analysis skills

• Assimilates data and research findings outside of Neurocrine for application to new scientific projects

• Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas

• Develops an understanding of other areas and related dependencies

• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools

• Strong ability to work as part of and lead multiple teams

• Excellent leadership skills and ability, typically leads multi-level teams and/or indirect teams

• Excellent computer skills

• Excellent communications, problem-solving, analytical thinking skills

• Sees broader picture, impact on multiple programs, teams and/or departments

• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency

• Emerging as an internal thought leader with technical and/or business expertise

• Applies in-depth knowledge of own area of expertise to solve problems

• Applies in-depth understanding and may guide others on how own discipline integrates within the department as well as impact to other departments and understands contribution to Neurocrine's achievement of business objectives

• Experience with cutting edge antibody modeling software and structure-based engineering approaches a plus

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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.

We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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