New

Medicinal Chemistry Senior Research Fellow

Vertex Pharmaceuticals Incorporated
paid time off, 401(k)
United States, Massachusetts, Boston
50 Northern Avenue (Show on map)
Jul 11, 2025
Job Description The Senior Fellow, Lead Chemist for Non-Viral Delivery, has an impressive history of accomplishments which contribute signicantly to the advancement of projects and is recognized internally and externally as a thought leader in the design, development, and implementation of non-viral delivery for therapeutic applications. The incumbent applies superior acumen in identifying project needs that are bolstered by refined, systematic creativity and strong judgment of when to launch efforts on a new trajectory. The Lead Chemist for Non-Viral Delivery will define the activities of a chemistry group and will be required to coordinate multiple teams to achieve project goals. KEY DUTIES and RESPONSIBILITIES Manages activities of the research group across project boundaries Mentors on scientic and ethical development, motivates personnel and resolves conicts Ensures personnel goal setting is effectively linked to corporate and department goals Oversee activities of staff and adapts personnel deployment to changing priorities, to ensure key goals of all projects are met on time Helps dene scientic and strategic directions and develop champions of technological innovation for the research group Directs effective, timely and ethical publication and patenting activities for the group Leads effective management of CRO contracts and/or external scientic collaborations Maintains the excellence of standards for structure and interpretation of all laboratory records, electronic database entries, internal reports, patents, and external communications from the group. Communicates company objectives to the group and availability of group resources and methods to Project Team(s), in a clear and timely manner, and develops abilities of others in this role Leads preparation of lucid scientic reports for all other branches and levels of the organization and its collaborators, presents expertly when called upon to various stakeholders and senior leadership Responsible for developing and cultivating and high achieving organization KNOWLEDGE and SKILLS Advanced expertise in state-of-the-art non-viral (e.g. LNP/VLP) delivery technologies for therapeutic applications with a focus on the discovery, development, and implementation of strategies for tissue-specific delivery (expert level) Expertise in lipid design and synthesis including the use of automation Deep knowledge in conjugation chemistry to advance drug delivery Demonstrated scientific productivity as evidenced by a strong publication record in top tier journals or equivalent industry accomplishment Highly developed scientic leadership qualities and established prowess integrating the activities of distinct functional groups across multiple projects. Greater aptitude for identifying productive new research initiatives/directions Experienced mentor who effectively infuses condence and team commitment Exhibits a record of excellent operational and ethical standards, and team-improvement Scientifically diverse and effective communicator Possesses greater knowledge of the drug development process and a keener awareness of issues therein Demonstrated success in resolving important organizational problems and/or infusing innovation EDUCATION and EXPERIENCE Ph.D. (or equivalent degree) in chemistry with 11+ years of relevant post-doctoral employment experience in medicinal and lipid chemistry. Strong track record of developing non-viral delivery technologies for therapeutic applications. #LI-KM4 Pay Range: $222,400 - $333,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com