Principal Scientist II to Senior Principal Scientist, Clinical PBPK Modeling & Simulation
 Novartis Group Companies | |
401(k)
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 United States, Massachusetts, Cambridge | |
 Nov 07, 2025 | |
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Job Description Summary #LI-HybridInternal Title: Principal Scientist II or Senior Principal Scientist (DUAL LEVEL) This position will be based in Cambridge, MA and will not be located remotely. The Modeling & Simulation group within PK Sciences is looking for a Principal Scientist II or senior Principal Scientist level modeler, to develop and apply translational physiologically based pharmacokinetic (PBPK) modeling along with data analysis techniques to facilitate drug discovery, development, and translational research across disease areas. Importantly, the candidate has experience with regulatory submissions and in successful regulatory interactions. The candidate's core responsibilities will include PBPK modeling to integrate in vitro and in vivo data for drug-drug interaction (DDI) assessments, impact of biopharmaceutics properties on absorption, and pharmacokinetic (PK) predictions in humans as well as in specific populations (e.g. disease, organ impairment, pediatrics). The ultimate goal of this work is to be on the forefront of applying PBPK models to inform the safe administration of our drug candidates in the clinic, to optimize clinical trial designs, and waive clinical trials, ultimately, to get our medicines to patients faster. You will have the opportunity to work in a dynamic and multidisciplinary environment to build, verify and apply quality translational/biopharmaceutical PBPK models. Job Description Key Responsibilities:
Essential Requirements:
This is a dual level posting. The final level and title of the offer role would be determined by the hiring team based on the skills, experience & capabilities required to perform the role at the level the role has been offered. The salary for this position is expected to range: Principal Scientist II: between $119,700 and $222,300 per year. Senior Principal Scientist: between $152,600 - $283,400 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here. EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $119,700.00 - $222,300.00Skills Desired Algorithms, Data Engineering, Innovation, Mentorship, Modeling And Simulation, Simulation Software, Waterfall Model | |