Sr. Scientist, Preformulation Pharmaceutical Development

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value.

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Job Summary (Primary function)

The Senior Scientist Preformulation, Pharmaceutical Development provides pre-formulation and formulation support to discovery programs in the pre-clinical phase. This role serves as an interface between Discovery and Pharmaceutical Development.

Essential Functions of the Job (Key responsibilities)

* Perform hands-on pre-formulation and formulation development for new small molecules in collaboration with Discovery.

* Characterize the physical and chemical properties of the drug candidate in collaboration with Chemistry.

* Leverage the physical/chemical and pharmacokinetic properties of the drug candidate to develop formulation strategies and options which include required resources to develop a clinical formulation.

* Manufacture lab scale suspensions, granulations, spray-dried dispersions, hot melts, tablets and other formulations utilizing bench-top equipment to support toxicology studies and clinical formulation development.

* Utilize animal models to screen formulations in collaboration with DMPK when appropriate.

* Maintain good documentation for laboratory experiments. Prepare data summaries and reports in collaboration with Discovery.

* Perform analytical testing and/or collaborate with analytical scientist. Analyze and interpret experimental data to form sound conclusions.

Qualifications (Minimal acceptable level of education, work experience, and competency)

* Degree (such as Ph.D. with at least 3 years of related experience; or MS with at least 5 years of related experience; or BS with at least 7 years of related experience) in pharmaceutical sciences or related field required.

* Experience with new small molecules at early stage of pipeline is required.

* Hands-on experience with preclinical formulation development and analytical testing. Experience with poorly soluble compounds is advantageous.

* In-depth understanding of preformulation and bioavailability enhancing formulation concepts.

* Knowledge of pharmacokinetics. Experience with Gastro-plus or similar PK modeling software is advantageous.

* Excellent communication skills, both verbal and written.

* Ability to work collaboratively in a fast-paced, matrixed, team environment consisting of team members from Discovery and Pharmaceutical Development.

* Analytical thinker with excellent problem-solving skills and the ability to adapt to changing priorities and deadlines.

* Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects simultaneously.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

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